SNTX-2643 is a novel, investigational, state-selective serotonin transporter modulator being developed for anxiety disorders

Company also announces appointment of Cole Brown, M.D., as Chief Medical Officer and formation of a Clinical Advisory Board

CAMBRIDGE, Mass., May 27, 2026 /PRNewswire/ — Sensorium Therapeutics, a clinical-stage central nervous system (CNS) biotechnology company developing mechanistically novel small-molecule medicines for psychiatric and neurological disorders, today announced that it will present the design of its ongoing Phase 1a clinical study of SNTX-2643, along with preclinical mechanistic data, at the 2026 American Society of Clinical Psychopharmacology (ASCP) Annual Meeting, taking place May 26-29 in Miami Beach, Florida.

SNTX-2643 is Sensorium’s lead investigational therapy from its SENS-01 program and is being developed for the treatment of anxiety disorders, including social anxiety disorder and generalized anxiety disorder. The compound is a novel, state-selective serotonin transporter (SERT) modulator designed to modulate SERT through a mechanism differentiated from currently marketed selective serotonin reuptake inhibitors (SSRIs).

The company also announced the appointment of Cole Brown, M.D., as Chief Medical Officer and the formation of a Clinical Advisory Board comprising leading experts in psychopharmacology, psychiatry, clinical trial design, and CNS drug development.

“Behind every statistic on anxiety is a person whose life has been narrowed by it, and far too many remain underserved by the treatments available today,” said Jacob Hooker, Ph.D., Co-Founder and Chief Executive Officer of Sensorium Therapeutics. “SENS-01 reflects our commitment to changing that through a mechanistically differentiated approach designed to address limitations patients and clinicians know all too well. The work being presented at ASCP, together with Cole’s leadership and the depth of our Clinical Advisory Board, underscores the rigor and clinical discipline guiding this program.”

ASCP 2026 Presentation

Title: The Pharmacokinetic Properties and Target Engagement Effects of the Novel Serotonin Transporter Modulator, SNTX-2643, in Healthy Adults

Poster Number: T10

Session: Thursday, May 28, 2026, 11:30 a.m.–1:15 p.m. Eastern

Presenting Author: Cole Brown, M.D., Chief Medical Officer, Sensorium Therapeutics

Authors: Andrew J. Cutler, M.D.; Cole Brown, M.D.; Jacob Hooker, Ph.D.; Jerry Rosenbaum, M.D.

Meeting: ASCP 2026 Annual Meeting

Location: Miami Beach, Florida

The poster will describe the design of Sensorium’s ongoing Phase 1a study of SNTX-2643. The presentation will also include preclinical phosphoproteomic analyses revealing a distinct downstream molecular signature for SNTX-2643 relative to fluoxetine. Topline Phase 1a results are expected in the second half of 2026.

“There remains a substantial unmet need for anxiety treatments that can address limitations of current options, including delayed onset, tolerability burden, sedation, and dependence concerns,” said Andrew Cutler, M.D., Clinical Professor of Psychiatry, SUNY Upstate Medical University and member of Sensorium’s Clinical Advisory Board. “SNTX-2643’s differentiated mechanism, together with the design of the ongoing clinical development program, creates an exciting opportunity to deliver a new treatment to help the millions of people and their families suffering with anxiety.”

About the Phase 1a Study

The Phase 1a study of SNTX-2643 is a randomized, double-blind, placebo-controlled, and open-label (food-effect cohort) clinical study designed to characterize the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profile of SNTX-2643 in healthy adult volunteers following single-dose administration, and to inform the design of subsequent clinical studies.

The study includes single-ascending dose cohorts designed to evaluate escalating doses of SNTX-2643; a target engagement cohort using quantitative electroencephalography (qEEG), including resting-state measures, event-related potentials, and an anxiety-inducing stimulus paradigm to characterize CNS target engagement; and a food-effect cohort designed to evaluate the impact of food on the rate and extent of SNTX-2643 absorption.

Safety is the primary endpoint of the study. Secondary endpoints include plasma PK, with exploratory endpoints including target engagement and qEEG measures.

Cole Brown, M.D., Appointed Chief Medical Officer

Dr. Brown will lead clinical development across Sensorium’s pipeline. He brings nearly 20 years of experience spanning clinical development, medical affairs, pharmacovigilance, and regulatory affairs across a range of therapeutic areas.

Dr. Brown joins Sensorium from Sage Therapeutics, where he served in roles of increasing responsibility within the Research and Development and Commercialization functions, through the company’s acquisition by Supernus Pharmaceuticals.

Earlier in his career, Dr. Brown led Medical Affairs and Clinical Development at Egalet, which was acquired by Zyla Life Sciences, now Cosette Pharmaceuticals, and worked as an independent consultant advising biotechnology companies.

He began his industry career at AlphaGroup, now Red Nucleus, where he contributed to nearly a dozen drug product launches. Dr. Brown serves on the alumni board of Temple University’s College of Science and Technology and is Co-Managing Partner of SCD Ventures.

“Sensorium has built a disciplined clinical development organization around a discovery platform designed to generate differentiated CNS medicines,” said Dr. Brown. “SNTX-2643 is a thoughtfully designed program around new pharmacology for a well-validated target, and I look forward to advancing it through Phase 1 and into patient studies with the rigor this program deserves.”

Clinical Advisory Board

Sensorium’s Clinical Advisory Board provides scientific and clinical guidance on the company’s development programs, including SNTX-2643 and future pipeline candidates.

Founding members include:

Andrew J Cutler, M.D.
Clinical Professor of Psychiatry, SUNY Upstate Medical University

Maurizio Fava, MD
Chair, Massachusetts General Brigham Psychiatry Department

Douglas Feltner, M.D.
Chief Medical Officer, Neurosterix

Napoleon Higgins, M.D.
CEO and President of Bay Pointe Behavioral Health Service, Inc.

K Ranga Krishnan, M.B.B.S.
Professor Emeritus, Duke University

Sanjay J Mathew, M.D.
Department Head, Psychiatry and Behavioral Sciences, Texas A&M College of Medicine

Charles B Nemeroff, M.D., Ph.D.
Matthew P Nemeroff Endowed Chair, Department of Psychiatry and Behavioral Sciences, University of Texas at Austin, Dell Medical School

Raymond Sanchez, M.D.
Senior Advisor, Bain Capital Life Sciences and Former Chief Medical Officer, Cerevel Therapeutics

Murray B Stein, M.D., M.P.H., FRCPC
Distinguished Professor of Psychiatry and Public Health, University of California San Diego

Jeffrey R Strawn, M.D., FAACAP
Dr. Henry and Amelia Nasrallah Endowed Professor in Psychiatric Neuroscience
Professor of Psychiatry & Behavioral Neuroscience
University of Cincinnati, College of Medicine
Department of Psychiatry & Behavioral Neuroscience

About SNTX-2643 (SENS-01 Program)

SNTX-2643 is Sensorium’s lead investigational therapy from the SENS-01 program and is being developed for social anxiety disorder, with potential applicability to generalized anxiety disorder and multiple other CNS disorders. It is a first-in-class precision serotonin modulator, differentiated from conventional SSRIs, designed for rapid onset, reduced off-target effects, and to avoid the sedation commonly associated with benzodiazepines.

About Sensorium Therapeutics

Sensorium Therapeutics is a clinical-stage central nervous system (CNS) biotechnology company developing mechanistically novel small-molecule medicines for psychiatric and neurological disorders. The company applies its proprietary SensAI discovery platform, which integrates chemistry, pharmacology, behavioral science, and neuroscience, to systematically predict drug candidates with differentiated mechanisms of action.

Founded by researchers from Harvard and Massachusetts General Hospital, Sensorium is advancing a pipeline led by SNTX-2643, a Phase 1 investigational therapy for anxiety disorders. The company’s pipeline also includes SENS-03, a preclinical program for treatment-resistant epilepsy, and SENS-08, a National Institutes of Health (NIH)-supported preclinical program targeting cognitive enhancement.

For more information, visit www.sensorium.bio.

Contact

Stefan Riley
Stefan.riley@sensorium.bio
617-461-2442

This press release contains forward-looking statements regarding Sensorium Therapeutics’ development programs, including anticipated clinical development activities, study timing, and potential therapeutic characteristics of investigational candidates. Actual results may differ materially from those expressed or implied by these forward-looking statements due to various risks and uncertainties inherent in drug development.

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SOURCE Sensorium Therapeutics